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The analysis showed that the risk of death or complications from Broken Heart syndrome remained high from 2016 to 2020

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Takotsubo -Kardiomyopathy, also known as Broken Heart syndrome, is associated with a high mortality rate and complications, and these rates are unchanged between 2016 and 2020, according to new research that has been published in the published Journal of the American Heart Association.

Takotsubo-cardiomyopathy is a stress-related heart disease in which part of the heart temporarily enlarged and does not pump well. It is believed that it is a reaction to an increase in stress hormones, which can be caused by an emotional or physically stressful event such as the death of a loved one or a divorce. It can lead to a difficult, short -term failure of the heart muscle and be fatal. Takotsubo cardiomyopathy can be diagnosed incorrectly as a heart attack, since the symptoms and test results are similar.

This study is one of the largest to evaluate the death rates and complications of the disease in the hospital, as well as gender, age and breed differences over five years.

“We were surprised that the mortality rate of Takotsubo-Kardiomyopathy without significant changes in the five-year study was relatively high, and the rate of complications in the hospital was also increased,” said the study author M. Reza Movahed, MD, Ph.D. “The continued high mortality rate is alarming, which indicates that more research is carried out for better treatment and that new therapeutic approaches are found for this condition.”

The researchers checked the health records in the nationwide inpatient trial database to identify people in whom Takotsubo's cardiomyopathy was diagnosed from 2016 to 2020.

The analysis showed:

  • The mortality rate was considered high in 6.5%, without improvement in the period.
  • Deaths in men were more than doubled in men at 11.2% compared to the rate of 5.5% in women.
  • The main complications included heart failure (35.9%), atrial fibrillation (20.7%), cardiogenic shock (6.6%), stroke (5.3%) and cardiac arrest (3.4%).
  • People older than 61 had the highest incidence rates of Takotsubo -Kardiomyopathy. However, there was a 2.6 to 3.25-fold incidence of this disease in adults aged 46 to 60 years aged 31 to 45 during the examination period.
  • White adults had the highest rate of Takoto -Tubo -Cardiomyopathy (0.16%), followed by adults of the American indigenous people (0.13%) and black adults (0.07%).
  • In addition, socio -economic factors, including medium -sized household income, hospital size and health insurance status, varied significantly.

“Takotsubo -Kardiomyopathy is a serious illness with a considerable risk of death and serious complications,” said Movahed. “The health team has to carefully check the coronary angiograms that do not have significant coronary disease with the classic appearance of a left ventricular movement, which indicates subtypes of stress -induced cardiomyopathy. These patients should be monitored and treated immediately.

“Some complications such as embolism stroke can be avoided by an early initiation of medication against anti-flaps in patients with an essentially weakened heart muscle or with an irregular heart rhythm, which is called atrial fibrillation, which increases the risk of stroke.”

He also found that age-related findings could serve as a useful diagnostic instrument between heart attack/breast pain and takotsubo-cardiomyopathy, which could cause the condition to diagnose earlier and also remove assumptions that tacotubo-cardiomyopathy only in the elderly.

One of the restrictions on the study is that it was based on data from hospital codes, who have mistakes or patients were more than admitted to the hospital or transferred to another hospital. In addition, there was no information about outpatient data, different types of Takoto -Tubo -Kardiomyopathy or other diseases that may have contributed to the death of the patients.

Movahed said that further studies on the treatment of patients with Takotsubo -Kardiomyopathy and the reason for the differences in the mortality rates between men and women are required.

Study endails, background and design:

  • The analysis comprised EUR 199,890 from all over the country (average age 67 years; 83% of cases were among women). White adults made up 80% of Takoto -Tubo -Cardiomyopathy patients, while 8% black adults, 6% Hispanic adults, 2% Asian/Pacific islanders were adults, 0.64% were adults of American indigenous people and 2.2% were reported than others.
  • The nationwide inpatient stab -off database is the largest publicly available source in the publicly and privately paid hospital care in the USA in detail and estimates inpatient capacity utilization, access, costs, quality and the results for around 35 million hospital stays at national level.

Further information:
High mortality and complications in patients who have been recorded with Takotsubo cardiomyopathy with more than double mortality in men without improving the result over the years, over the years. Journal of the American Heart Association (2025). DOI: 10.1161/Jaha.124.037219

Provided by American Heart Association

Quote: The analysis results in the risk of death or complications in the Broken Heart syndrome from 2016 to 2020 (2025, May 14), accessed on May 14, 2025 from high

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