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Congenital pharma emphasizes Anket® abstracts that were selected for the EHA 2025 congress

Marseille, France, May 15, 2025-(Business Wire)-Regulatory News:

Congenital pharma SA (Euronext Paris: iPh; Nasdaq: iPha) (“Innate“Or that”Pursue“) Today it was announced that a summary regarding IPH6501, his anchor® The targeting of CD20-B cells, which were currently being developed in recurrent and/or refractory non-Hodgkin lymphoma, was selected for the Congress European Hematology Association (EHA) in 2025, which takes place in Milan, Italy from June 12th to 15th.

Summary Details

Antitumor characterization of IPH6501, a new IL2V-armed tetras-specific NK-Zell-Man, which aims on CD20-B cells, in DLBCL and FL patient samples and in preclinical combination with R-chop
Summary code: PS2004
Meeting: Poster session 2
Session date/time: Saturday, June 14, 2025, 6:30 p.m. – 7:30 p.m. CEST
You can find more information on the EHA website.

In addition, a summary with SAR'514/IPH6401 (developed by Sanofi) for online publication was accepted.

The BCMA NK cell engagement SAR'514 induces macrophage-mediated phagocytosis, which is improved in multiple myeloma by combination with Evorpacept, a CD47 blocker
Summary code: PB2850

About Annket®

Hinge® ((ANtibody-based NK cell ENgager THerapeutics) is the proprietary platform of Innate for the development of the NK-Zell-Gengors of the next generation, multi-specific natural killers (NK) for the treatment of certain types of cancer. This versatile, suitable technology creates a completely new class of molecules to induce synthetic immunity against cancer.

About iPh6501

IPh6501 is the first antibody-base-based NK Cell Engager Therapeutic to co-energage Activating Receptors on NK Cells (NKP46 and CD16), IL-2R (but not the alpha subunit) through human il-2, and a tumor antigen (CD20) via a single molecule, hence Providing Proliferation and Activation Signals Targeted to NK Cells and Promoting their cytotoxic activity against CD20 that expresses malignant cells.

IPH6501 has shown a better effectiveness of antitumors as an approved benchmark antibody in preclinical tumor models (Demaria, EHA 2023, Carrette, Sitc 2024, Demaria et al., Science Immunology 2024).

The IPH6501 is currently evaluated in a multi-center study of phase 1/2 (NCT06088654), in which the safety and tolerance of IPH6501 is examined in patients with recurrent and/or refractory CD20-expressing B cell-not-Hodgkin-lymphoma.

About congenital pharmaceutical

The congenital Pharma SA is a global biotechnology company in the clinical stage that develops immunotherapy for cancer patients. Its innovative approach aims to use the innate immune system through three therapeutic approaches: multi-specific NK-Zell-Gengpass via his anchor® (Therapeutic drugs on antibody base NK Cell Engager) Proprietary platform and antibody drug conjugate (ADC) and monoclonal antibodies (MABS).

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