Clinical score for a high liver iron content in hyperferitinemia

Photo loan: Yaruniv studio

The following is a summary of a “clinical predictive scores with a high liver iron content in metabolic hyperferitinemia: a retrospective cohort pilot study”, which was published in May 2025 edition of BMC Gastroenterology By Boughthzala et al.

The researchers carried out a retrospective study in order to develop a clinical prediction value for the high liver iron content (lic) in metabolic hyperferitinemia (MH) in order to direct the use of magnetic resonance imaging (MRI) of the liver.

They examined patients with MH who were subjected to a lic -rating during the diagnosis. Patients with excessive alcohol consumption were excluded. A multivariate analysis, followed by a replica analysis of 1000 boat trap using an expectation maximization algorithm, was carried out in order to identify predictive factors of high LIC. A ROC analysis (receiver operative curve) was created in order to evaluate the performance of the prediction value based on quotas (OR) from the multivariate analysis.

The results showed that 217 patients (180 men, average age 57 years) were enclosed, with 55 patients (25%) with high lic (≥ 100 µmol/g) with high lic (≥ 100 µmol/g). An univariate analysis showed that a family medical history of hyperferitinemia, which requires phlebotomies and transferrin saturation> 45% (P<0.001) were associated with high lic. Multivariate regression identified significant associations with high lic to a family history of hyperferitinemia ([OR] 6.15, CI95 [2.11–17.92]), Ferritin level ≥ 600 µg/l (or 5.53, CI95 [1.43–21.42]) and transferrin saturation ≥ 45% (or 2.63, CI95 [1.32–5.23]). A 15-point prediction value was developed, with an area and curve (AUC) of 0.72 (CI95 [0.64–0.79]Present P<0.001), which results in one or 4.17 (CI95) [2.15–8.07]Present P<0.001), sensitivity of 60%, specificity of 97%and negative prediction value of 84%.

The investigators came to the conclusion that Ferritin ≥ 600 µg/l, transferrin saturation ≥ 45%and a family history of hyperferitinemia, which required blood injury, was a reliable clinical evaluation to predict a high LIC in metabolic adult canalinemia, with the boat trap analysis that the robustness of the model of the model confirmed.

Source: bmcgastroenterol.biomedcentral.com/articles/10.1186/S12876-03891-2