High Gleason score: Understanding of signs and treatment of symptoms of prostate cancer

Prostate cancer are among the most common types of cancer in men, the forecast and treatment of which mainly depends on the Gleason valuation system. The most recent diagnosis of the former president of the United States, Joe Biden, with an aggressive form of prostate cancer underlines the extremely important role of the evaluation system in daily practice.Understanding of the Gleason.The Gleason score is the histopathological evaluation system for evaluating the architectural patterns of prostate cancer cells in biopsies. The ratings range from 6 to 10 and higher values ​​indicate virulent and poorly differentiated tumors. As in the case of President Biden, a Gleason value of 9 is a high-quality cancer with a high level of progression and metastasis.Clinical importance of a high Gleason scoresA Gleason score of 9 sets up the cancer in Grad Group 5, the highest group. High -quality tumors tend to grow beyond the capsule, penetrate the seed bubbles and spread far on bones. In bidens situation, cancer is also spread on the bones, so that an advanced cancer.Regular screening through clinical examination and PSA is the most important thing in the early detection of prostate cancer. A routine health check is recommended for men over 60 years.Treatment considerationsAlthough the prostate cancer with high Gleason score have progressed, there are several treatment options. Androgen withdrawal therapy (ADT) can be used to treat hormone -sensitive tumors such as bidges by reducing the testosterone level to delay cancer. Another therapy can include chemotherapy and radiation treatment, depending on the general health of the patient and the rate with which the cancer progresses.The role of early detectionThe diagnosis of biden underlines the challenges of early identification of dangerous prostate cancer. While routine screening with prostate-specific antigen tests (PSA) can identify problems, their sensitivity to high-grade cancer is uncertain. In addition, the advantages of the mass screening with PSA are questionable due to the problem of overdiagnosis and oversurance.Improve diagnostic devicesTechnologies such as multiparametric MRI, PSMA PET scans and AI-based pathology also improve the accuracy of recognizing prostate cancer and glacing rating.These technologies can identify suspicious areas with greater accuracy and reduce the interobership variation in classification, which enable more precise treatment planning.DiplomaThe Gleason score remains a standard for the diagnosis and treatment of prostate cancer. President Biden's most recent diagnosis with an aggressive Gleason score -cancer shows the benefits of this evaluation system when choosing treatment. When diagnostic technology improves, it promises to improve the early detection and personalized care of patients who face this demanding illness.(Article with friendly approval: Dr. Mangesh Patil, Senior Minimal Invasive Urology and Endourology – renal sciences, Sir HN Reliance Foundation Hospital. Mumbai).